Detection of differences in liver protein composition between recombinant strains of mice with different ThioTEPA sensitivities |
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| Authors: | Malashenko A M Beskova T B Kovaleva M A Kovalev L I |
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| Institution: | Research Laboratory of Experimental Biological Models, Russian Academy of Medical Sciences, Moscow oblast, Russia. |
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| Abstract: | The sensitivity of recombinant mouse strains subjected to 23-27 generations of inbreeding to the clastogenic effect of thioTEPA (triethylene thiophosphoramide) was reestimated, and their characteristics were confirmed. Six 1XC3 recombinant strains were obtained from crossing strains 101/H x C3H/Sn, which differed from one another with respect to the sensitivity to thioTEPA. The protein composition of the liver tissue was studied in the recombinant strains by means of two-dimensional electrophoresis. Interstrain differences with respect to five liver proteins were found, which were correlated with the differences in the response to the mutagen. |
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