The prediction of the structural class of protein: application of the measure of diversity. |
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Authors: | Q Z Li Z Q Lu |
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Institution: | Laboratory of Theoretical Biophysics, Inner Mongolia University, Hohhot, 010021, China. qzli@mail.imu.edu.cn |
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Abstract: | Based on the concept that the structural class of a protein is mainly determined by its secondary structure sequence, a new algorithm for prediction of the structural class of a protein is proposed. By use of the number of alpha -helices, beta -strands, and betaalphabeta fragments, the structural class of a protein can be predicted by an algorithm based on the increment of diversity (ID), in which the sole prediction parameter-the increment of diversity is used as the index of prediction of structural class of a protein. The results indicate that the high rates of correct prediction are obtained for complete set (standard set) from Brookhaven Protein Data Bank-CD ROM (PDB) published in October 1995 and the test set newly released from Brookhaven Protein Data Bank-CD ROM (PDB) before July 1998, respectively. |
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