A UV Resonant Raman Spectroscopic Study of the Interaction of Metallic Derivatives of Tetrakis(4-N-methylpyridyl)porphine with Polynucleotides |
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| Authors: | G V Wheeler A Laigle L Chinsky |
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| Institution: | Equipe ESTER, L.P.B.C. (CNRS URA 2056), Case 138, Université Pierre et Marie Curie , 4 Place Jussieu, 75252 , Paris, Cedex 05 , France |
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| Abstract: | Abstract Resonance Raman spectra excited at 257 nm are reported for the complexes of the Nickel, Cobalt and Zinc derivatives of Tetrakis(4-N-methylpyridyl)porphine with poly(dA.dT)2, poly(dA)poly(dT), poly(dG.dC)2 and poly(dG).poly(dC). These spectra are interpreted as evidence of multiple outside binding modes with poly(dA).poly(dT), and of evidence for an outside binding mode with Poly(dG.dC)2. Some results obtained for the zinc derivative with poly(dA).poly(dT) suggest a binding mode peculiar to this derivative. |
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| Keywords: | Chromatin code DNA bendability Nucleosome DNA Nucleosome positioning Nucleosome structure |
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