Evidence for GABAergic fibers entering the superior cervical ganglion of rat from the preganglionic nerve trunk |
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| Authors: | E Dobó P Kása R J Wenthold F Joó J R Wolff |
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| Institution: | (1) Central Research Laboratory, Albert Szent-Györgyi Medical University, Somogyi B. u. 4, H-6720 Szeged, Hungary;(2) Laboratory of Neuro-Otolaryngology, National Institute of Neurological and Communicative Disorders and Stroke, NIH, 20892 Bethesda, MD, USA;(3) Institute of Biophysics, Biological Research Center, H-6701 Szeged, Hungary;(4) Department of Anatomy, University of Göttingen, D-3400 Göttingen, Federal Republic of Germany |
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| Abstract: | Summary The origin of gamma-aminobutyric acid immunoreactive (GABA-IR) nerve fibers present in the superior cervical ganglion (SCG) of rat was investigated. With immunocytochemical techniques many nerve fibers showed GABA-like positivity in the cervical sympathetic trunk, whereas similar staining could not be revealed in the internal carotid nerve or in the external carotid nerve. Ligation of the cervical sympathetic trunk for 24 h resulted a dramatic reduction in the staining density in the ganglion and in the cervical sympathetic trunk distal to the ligature. After transection of the preganglionic nerve fibers for eleven days or more, very few fibers staining for GABA were seen in the ganglion. The immunohistochemical results suggest that a major source of GABA within the SCG is a population of GABAergic axons entering from the preganglionic trunk. |
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