Vasoactive intestinal peptide (VIP)-like immunoreactivity in the human sympathetic ganglia |
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| Authors: | R Järvi P Helen A Hervonen M Pelto-Huikko |
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| Institution: | (1) Department of Biomedical Sciences, University of Tampere, P.O. Box 607, SF-33101 Tampere, Finland;(2) Department of Public Health, University of Tampere, P.O. Box 607, SF-33101 Tampere, Finland |
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| Abstract: | Summary Vasoactive intestinal peptide immunoreactive (VIP-IR) nerve fibres and terminals, neurons and small granule containing cells were observed in human lumbal sympathetic ganglia. Electron-microscopically VIP-IR was localized in the large dense-cored vesicles in nerve terminals and on the membranes of the Golgi complexes in the neurons. A small population of principal ganglion cells was surrounded by VIP-IR nerve terminals. Most of these neurons contained acetycholinesterase (AChE) enzyme but were not tyrosine hydroxylase-immnoreactive (TH-IR). All VIP-IR ganglion cells and most of the nerve fibres contained AChE but not TH-IR. It appears that in human sympathetic ganglia VIP is localized in the cholingergic neurons and nerve fibres and that the VIP-IR nerve terminals innervate mainly the cholinergic subpopulation of the sympathetic neurons. |
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