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Evolving maps in craniofacial development
Authors:Yorick Gitton  Églantine Heude  Maxence Vieux-Rochas  Laurence Benouaiche  Anastasia Fontaine  Takahiro Sato  Yukiko Kurihara  Hiroki Kurihara  Gérard Couly  Giovanni Levi
Institution:1. Évolution des Régulations Endocriniennes, CNRS UMR 7221, Muséum National, d’Histoire Naturelle, 75231 Paris Cedex 05, France;2. Service de Chirurgie Plastique, Maxillofaciale et Stomatologie, Hôpital Necker-Enfants Malades, 149, rue de Sèvres, 75015 Paris, France;3. Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan;1. Department of Surgery, Michigan State University, United States;2. Pediatric Specialty Care, East Carolina University, United States;3. Department of Neurology, The Ohio State University, United States;4. Department of Otolaryngology Head and Neck Surgery, University of North Carolina School of Medicine, Chapel Hill, NC, United States;5. Division of Sleep and Epilepsy, Department of Neurology, University of North Carolina School of Medicine, United States;3. State Key Laboratory of Oral Diseases, Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041 Sichuan, China;4. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, 610041 Sichuan, China;5. Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118;6. Southern Center for Biomedical Research and Fujian Key Laboratory of Developmental and Neuro Biology, College of Life Sciences, Fujian Normal University, Fuzhou, 350117 Fujian, China;1. Division of Developmental Biology, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH 45229, USA;2. Division of Plastic Surgery, Cincinnati Children''s Hospital Medical Center, Cincinnati, OH 45229, USA
Abstract:The shaping of the vertebrate head results from highly dynamic integrated processes involving the growth and exchange of signals between the ectoderm, the endoderm, the mesoderm and Cephalic Neural Crest Cells (CNCCs). During embryonic development, these tissues change their shape and relative position rapidly and come transiently in contact with each other. Molecular signals exchanged in restricted regions of tissue interaction are crucial in providing positional identity to the mesenchymes which will form the different skeletal and muscular components of the head. Slight spatio-temporal modifications of these signalling maps can result in profound changes in craniofacial development and might have contributed to the evolution of facial diversity. Abnormal signalling patterns could also be at the origin of congenital craniofacial malformations. This review brings into perspective recent work on spatial and temporal aspects of facial morphogenesis with particular focus on the molecular mechanisms of jaw specification.
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