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Molecular processes in the streptokinase thrombolytic therapy |
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| Authors: | Cristian Capitanescu Anca Monica Macovei Oprescu Dan Ionita Gabi Valeriu Dinca Claudiu Turculet Gheorghe Manole |
| Institution: | 1. S.C. Ecodet Activ S.R.L, Fizicienilor No.22, BL.21A, Sc.1, Ap.22, Bucharest, 3, Romania,;2. National Environmental Protection Agency, Splaiul Independentei No. 294, Bucharest, 6, Romania, cristian.capitanescu@yahoo.com;4. Carol Davila University of Medicine and Pharmacy, Dionisie Lupu No. 37, Bucharest, 1, Romania,;5. Clinical Hospital Grigore Alexandrescu, Iancu De Hunedoara No. 30-32, Bucharest, 1, Romania,;6. University “Titu Maiorescu”, Gheorghe Petrascu No. 67A, Bucharest, 3, Romania, and;7. University “Titu Maiorescu”, Gheorghe Petrascu No. 67A, Bucharest, 3, Romania, and;8. Clinical Hospital Colentina, Stefan Cel Mare No. 19–21, Bucharest, 2, Romania |
| Abstract: | The aim of this research is to evaluate the current streptokinase thrombolytic treatment and to identify or improve new techniques that will base new approaches with a higher efficiency in this area of expertise. In order to be as realistic as possible a new method was set up using magnetic vectorized nanoparticles streptokinase and human blood thrombus. The experimental data confirm the maximum 83% thrombus lyses whenever increase streptokinase concentration. It is very probable to happen because of the presence of high concentration of antiplasmin in the blood that neutralizes around half of the thrombolytic potential of the sanguine plasminogen. The experiment shows also that only free serum plasminogen are available for streptokinase action in order to generate plasmin. |
| Keywords: | Antiplasmin magnetic nanoparticle streptokinase thrombus |