Binding of Transition Metal Ions [Cobalt,Copper, Nickel and Zinc] with Furanyl-, Thiophenyl-, Pyrrolyl-, Salicylyl-and Pyridyl-Derived Cephalexins as Potent Antibacterial Agents |
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| Authors: | Zahid H Chohan Humayun Pervez Khalid Mohammed Khan A Rauf |
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| Institution: | 1. Department of Chemistry, Bahauddin Zakariya University, Multan, Pakistan;2. HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, 75270, Karachi, Pakistan;3. Department of Chemistry, Islamia University, Bahawalpur, Pakistan |
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| Abstract: | A method is described for the preparation of novel cephalexin-derived furanyl-, thiophenyl-, pyrrolyl-, salicylyl- and pyridyl-containing compounds showing potent antibacterial activity. The binding of these newly synthesized antibacterial agents with metal ions such as cobalt(II), copper(II), nickel(II) and zinc(II) has been studied and their inhibitory properties against various bacterial species such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae are also reported. These results suggest that metal ions to possess an important role in the designing of metal-based antibacterials and that such complexes are more effective against infectious diseases compared to the uncomplexed drugs. |
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| Keywords: | antibacterials metal complexes cephalexin |
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