Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase |
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| Authors: | Mikhail Krasavin Raivis ?alubovskis Aiga Grandāne Ilona Domra?eva Petr Zhmurov |
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| Institution: | 1. Department of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation m.krasavin@spbu.ru;3. Latvian Institute of Organic Synthesis, Riga, Latvia;4. Faculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, Riga, Latvia;5. Latvian Institute of Organic Synthesis, Riga, Latvia;6. Department of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation |
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| Abstract: | Abstract The hypothesis that sulfocoumarin acting as inhibitors of human carbonic anhydrase (CA, EC 4.2.1.1) cancer-associated isoforms hCA IX and – hCA XII is being able to also inhibit thioredoxin reductase was verified and confirmed. The dual targeting of two cancer cell defence mechanisms, i.e. hypoxia and oxidative stress, may both contribute to the observed antiproliferative profile of these compounds against many cancer cell lines. This unprecedented dual anticancer mechanism may lead to a new approach for designing innovative therapeutic agents. |
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| Keywords: | Anticancer agents carbonic anhydrase inhibition thioredoxin reductase inhibition hypoxia oxidative stress |
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