Synthesis of 5-aryl-6-cinnamoyl-7-methyl-flavanones as novel antioxidants and antihyperlipidemics |
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Authors: | Sharma Anindra Anand Namrata Sharma Rahul Chaturvedi Upma Khanna A K Bhatia Gitika Tripathi Rama P |
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Institution: | Medicinal and Process Chemistry Division, Central Drug Research Institute Lucknow, CSIR, India. |
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Abstract: | An economical and efficient one-pot synthesis of a series of novel 5-aryl-6-cinnamoyl-7-methyl-flavanones has been developed by simple refluxing of cinnamoyl chalcones with NaOAc in aqueous ethanol in quantitative yields. These flavanones were screened for their in vitro antioxidant and in vivo antidyslipidemic activities. Among 24 compounds screened, four compounds 28, 29, 30, and 48 showed significant antidyslipidemic activities. However, out of all the compounds, only compound 28 exhibited significant antioxidant activity and other compounds showed moderate antioxidant activities. |
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