微环境对细胞的影响以及仿生学在组织工程支架中的应用

微环境影响着细胞的增殖、迁移、分化以及细胞功能，细胞微环境影响细胞命运的因素包括细胞之间相互作用、细胞与细胞外基质相互作用、可溶性信号分子以及缺氧和营养对细胞的影响。组织工程支架的制备就是要利用仿生学原理最大程度模拟细胞微环境，从而应用于细胞行为研究以及临床治疗。全面了解细胞微环境对细胞的影响因素是制备组织工程支架的重要条件，而组织工程支架的研究也进一步推动了细胞微环境对细胞影响的认识。组织工程支架研究在组织工程研究中仍具有广阔前景，新的制备工艺也在组织工程支架研究中发挥着巨大推动作用。

The Effects of Microenvironment on Cells and The Application of Bionics in Tissue Engineering Scaffolds

Microenvironment effects proliferation, migration and functions of cells. The factors of microenvironment that effect fate of cells include interactions between cells and extracellular matrix, soluble signal molecules, anoxia and nutrition. To prepare engineering tissue scaffold need to simulate the cells microenvironment furthest following the bionics theory so that the scaffold can be used in studies of cell behaviour and clinical therapy. Comprehensive understanding the effects factors of microenvironment on cells played an important role on tissue engineering scaffold preparation, and the studies about tissue engineering scaffold also promoted the knowledge about microenvironment effect on cells. Researches on tissue engineering scaffolds have broad prospects in the field of tissue engineering. And new preparation techniques also play a huge role in promoting the research on tissue engineering scaffold.