细菌对氨基糖苷类抗生素产生抗性的机理及其控制策略

氨基糖苷类抗生素在治疗感染性疾病尤其是革兰氏阴性菌引起的严重感染方面起着重要作用 ,但是耐药菌株的出现较大地限制了此类抗生素的发展 ,因此 ,如何控制耐药性已经成为一项迫切需要解决的任务。细菌对氨基糖苷类抗生素产生抗性的机制很多 ,目前普遍接受的主要有三种 :1. 通过减少对氨基糖苷类抗生素的摄取或减少药物在体内的累积而产生抗性。 2. 通过改变核糖体结合位点而产生抗性。 3. 通过表达氨基糖苷类抗生素修饰酶而产生抗性。目前细菌耐药性的控制主要集中在对原有氨基糖苷类抗生素进行改造或合成新的抗生素 ,开发氨基糖苷类抗生素修饰酶抑制剂。

Mechanisms and Control Strategies of Bacteria Aminoglycoside Antibiotic Resistance

Aminoglycoside antibiotics are valuable and sometimes indispensable for the treatment of various infections especially those that are caused by Gram-negative strains.But the emergence of resistant strains has somewhat reduced the development of aminoglycosides.Therefore,how to control bacteria resistance has been one of the pressing tasks in this research field.Many mechanisms have been proposed but only three are widely accepted:1.decreased uptake and/or decreased accumulation of aminoglycoside antibiotics of bacteria.2.alteration of the ribosomal binding sites.3.expression of enzymes which inactivate aminoglycoside antibiotics by modifying their structure.So far,approaches to control bacterial aminoglycoside antibiotics resistance are mostly focused on the following:to modify the structure of known antibiotics or synthesis new structural aminoglycoside antibiotics;develop inhibitors of aminoglycosides modifying enzymes.;