端粒保护蛋白1(POT1)的研究进展

端粒保护蛋白1(protection of telomeres 1,POT1)几乎存在于所有真核生物中,是一种高度保守表达的蛋白质,它与一系列相关的端粒结合蛋白共同参与保护端粒的结构和功能。随着近年来研究的深入,POT1与端粒的结合特点以及保护端粒的机制有了进一步的完善。此外,POT1对端粒长度的调节方式以及与肿瘤的发生、发展和细胞凋亡等关系也呈现出多样化。结合近几年的研究文献,对POT1的功能以及与其它相关蛋白的作用加以综述。

Advances of The Protection of Telomeres 1

POT1(protection of telomere 1) was found in unicellular organisms by Baumann in 2001,which have been identified and expressed highly conserved in a wide range of eukaryotes.It plays pivotal roles in protection of chromosome end and regulation of telomere length with other telomeric binding proteins.With the advances of POT1,the mechanisms have being gradually completed due to the new founds in the DNA binding feature of POT1 and chromosome end protection.Furthermore,the ways in which POT1 regulates telomere length has been found being more complex;and how POT1 allows the cell immortalization and promotes tumor progression and induces cell apoptosis have been more clear.As reference recent journals,the article summarizes the functions of POT1 proteins and discusses the interaction with other related proteins.