| bcr/abl嵌合基因与白血病分子机制 |
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| 引用本文： | 韩金祥.bcr/abl嵌合基因与白血病分子机制[J].中国生物工程杂志,2001,21(1):19-22. |
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| 作者姓名： | 韩金祥 |
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| 作者单位： | 山东省医药生物技术研究中心 济南 250062 |
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| 摘 要： | bcr/abl嵌合基因是白血病ph染色体的分子基础,其表达的融合蛋白具有活跃的酪氨酸激酶活性,它与细胞信号传导功能有关的蛋白作用干扰细胞正常信号的传导,影响细胞生长或凋亡。bcr/abl在白血病中的作用机制的进一步阐明有助于白血病的治疗。
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| 关 键 词： | bcr/bal嵌合基因 白血病 |
The chimeric bcr/abl gene and molecular mechanism of leukemia |
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| Han Jinxiang.The chimeric bcr/abl gene and molecular mechanism of leukemia[J].China Biotechnology,2001,21(1):19-22. |
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| Authors: | Han Jinxiang |
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| Abstract: | The chimeric bcr/abl gene is a molecular basic of leukemia with Ph Chromosome,it expresses chimeric proteins(P bcr/abl 210 and P bcr/abl 190 ) with high tyrosine kinase activity bind and phosphorylat some cell signalling proteins and affect cell amplification and/or apoptosis,The bcr/abl gene can transform hematopoietic cell easily,and It is not clear why in some circumstances bcr/abl cause chronic leukemia and in others acute leukimia.Hopefully,better understanding of mechanisms of bcr/abl induced transformation will produce more effective treatment of leukemia. |
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| Keywords: | chimeric bcr/abl gene leukemia mechaniX |
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