| RNA疗法产业发展态势分析及建议 |
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| 引用本文： | 杨若南,许丽,徐萍,苏燕.RNA疗法产业发展态势分析及建议[J].中国生物工程杂志,2021(2):162-171. |
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| 作者姓名： | 杨若南 许丽 徐萍 苏燕 |
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| 作者单位： | 中国科学院上海生命科学信息中心中国科学院上海营养与健康研究所 |
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| 基金项目： | 国家重点研发计划(2016YFC0901904);上海市科委软科学项目(18692109100)资助项目。 |
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| 摘 要： | 近年来,反义寡核苷酸药物、siRNA药物的相继获批上市,标志着RNA疗法已逐渐从研究走向了产业化应用。目前RNA疗法已可应用于罕见病、肿瘤、感染性疾病等多种疾病的治疗。我国在RNA疗法产业上已有一定基础,但与国际相比,从事RNA疗法研发机构较少,研发管线单薄且缺乏核心技术,研发动力不足。对国内外RNA疗法领域产业发展态势进行梳理,分析我国RNA疗法的发展现状,提出发展对策建议。
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| 关 键 词： | ASO SIRNA MRNA |
The Development Situation and Suggestions of RNA Therapy Industry |
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| YANG Ruo-nan,XU Li,XU Ping,SU Yan.The Development Situation and Suggestions of RNA Therapy Industry[J].China Biotechnology,2021(2):162-171. |
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| Authors: | YANG Ruo-nan XU Li XU Ping SU Yan |
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| Institution: | (Shanghai Information Center for Life Seiences,Shanghai Institute of Nutrition and Health,Chinese Academy of Sciences,Shanghai 200031,China) |
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| Abstract: | In recent years,with a growing number of approved ASO and siRNA drugs,RNA therapy has gradually moved from clinical to industrial application,and RNA therapy currently can be applied to the treatment of rare diseases,tumors,infectious diseases and others.On the whole,a certain foundation on domestic RNA therapy industry has been built,while few engaged institutions,weak research pipelines and lacking of key technologies are still the main reasons that limit the development of RNA therapy industry in China.The development trends of RNA therapy industry at home and abroad are combed and analyzed,and then some suggestions for the development of RNA therapy in China are put forward. |
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| Keywords: | ASO siRNA mRNA |
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