| sLea/x与肿瘤血源性转移研究进展 |
| |
| 引用本文： | 彭云丽,李静,耿美玉.sLea/x与肿瘤血源性转移研究进展[J].中国生物工程杂志,2007,27(6):92-95. |
| |
| 作者姓名： | 彭云丽 李静 耿美玉 |
| |
| 作者单位： | 中国海洋大学 中国海洋大学 |
| |
| 基金项目： | 国家重点基础研究发展计划(973计划) |
| |
| 摘 要： | 肿瘤细胞表面sLea/x的表达水平与组织病理学参数正相关，且是转移性疾病的一个很重要的预后指标1]。ssLea/x与其配体E-选择素的结合启动了肿瘤血源性转移的发生。sLea/x与其配体的相互作用需要一定的活性构象，而基于模拟sLea/x的生物活性结构而设计的一类小分子化合物，可以有效地抑制sLea/x与其配体的结合，从而发挥抗肿瘤作用。本论文对近年来sLea/x与肿瘤血源性转移关系的研究及相关药物开发进行了综述。
|
| 关 键 词： | sLea/x 肿瘤 血源性转移 活性构象 |
| 收稿时间： | 2006-12-04 |
| 修稿时间： | 2006-12-042007-01-26 |
Studies on sLea/x and hematogenous metastasis of cancer |
| |
| PENG Yun-li,LI Jing,GENG Mei-yu.Studies on sLea/x and hematogenous metastasis of cancer[J].China Biotechnology,2007,27(6):92-95. |
| |
| Authors: | PENG Yun-li LI Jing GENG Mei-yu |
| |
| Institution: | School of Medicine and Pharmacy,Ocean University of China, Qingdao 266003,China |
| |
| Abstract: | The expression of sLea/x which correlates with conventional histopathologic parameters serves as a useful indicator for the prognosis of metastatic disease. The bindings between sLea/x and their common ligand E-selectin initiate hematogenous metastasis of cancer. Certain bioactive conformation is crucial for the interaction between sLea/x and their ligands. Thus, a new class of compounds that mimic the structures of sLea/x can potently inhibit not only their functional bindings to selectins, but also the metastasis of cancer. This review is mainly on the sLea/x molecular structure,biosynthesis,distribution, especially the relationship between sLea/x and hematogenous metastasis of cancer and the design of drugs that mimic the structures of sLea/x. |
| |
| Keywords: | sLe~(a/x) Cancer Hematogenous metastasis Bioactive conformation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《中国生物工程杂志》浏览原始摘要信息 |
| 点击此处可从《中国生物工程杂志》下载免费的PDF全文 |
