抗菌肽改良设计及抗炎作用的研究进展

抗菌肽因其具有广谱抗菌活性、不容易引起抵抗性,被认为是先天免疫系统对抗微生物感染的多功能工具。然而,天然抗菌肽存在抗菌活性低、稳定性低、溶血性高等问题,使其较难应用于临床,所以研究人员对抗菌肽进行改良设计以期获得更高抗菌活性、更低溶血活性的新型抗菌肽。另外,天然抗菌肽作为一类免疫效应因子而被发现,其表现出的抑菌、免疫调节、内毒素中和等作用,使得研究人员对抗菌肽在抗炎作用的研究表现出极大的兴趣。就抗菌肽的药物设计方法及抗炎作用机制进行综述。

The Development of Optimized Design and Anti-inflammatory Mechanisms of Antimicrobial Peptides

Because antimicrobial peptides have a broad spectrum of antimicrobial activity and are not easy to cause resistance, it are understood abroad multifunctional tools of the innate immune system to fight microbial infections.However, the antimicrobial activity and stability of natural antimicrobial peptides is lower, and hemolytic activity of antimicrobial peptides is higher, resulting in more difficultly applying to clinical trials. So researchers optimize to design it to achieve the newly antimicrobial peptides of higher antimicrobial activity and lower hemolytic activity. In addition, natural antimicrobial peptides are discovered as a class of immune effectors, resulting from antimicrobial activity , immunomodulatory activity and the ability of neutralizing endotoxin of antimicrobial peptides and so on. So researchers are more interested in its anti-inflammatory development. Optimized design and anti-inflammatory mechanism of antimicrobial peptides are reviewed.