肌源干细胞可塑性研究进展

目前已证实肌肉中至少存在两种干细胞:肌卫星细胞和肌源干细胞。肌源干细胞被认为是卫星细胞的前体细胞,具有较高的增殖能力、更好的细胞生存能力和更宽的分化能力。肌源干细胞不仅能够分化成血、肌肉、脂肪、骨、软骨、内皮等中胚层细胞,而且也能打破胚层限制分化成外胚层和内胚层细胞。文章对肌源干细胞的分离纯化、鉴定、可塑性及临床应用做一综述。

Progress on the Plasticity of Muscle-derived Stem Cell

Two types of stem cells in muscle: satellite cells and muscle-derived stem cells (MDSCs) have been identified. MDSCs, a predecessor of the satellite cell, are considered to possess a higher regeneration capacity and to exhibit better cell survival and a broader range of multilineage capabilities. MDSCs are not only able to differentiate into mesodermal cell types including the myogenic, adipogenic, osteogenic, chondrogenic, endothelial, and hematopoietic lineages, but also possess the potential to break germ layer commitment and differentiate into ectodermal and endodermal lineages under certain conditions. The progress on isolation, identification, plasticity, and the current clinical applications of MDSCs are reviewed.