动物细胞培养过程中的细胞凋亡

细胞培养过程中的细胞凋亡是细胞受环境因素的影响而发生的现象。随着对细胞凋亡的分子生物学和细胞生物学了解的深入，显示了有效地控制动物细胞培养中细胞凋亡的巨大潜力。包括采用ＤＮＡ重组技术把抗细胞凋亡的基因导入细胞和在培基中加入具有抗细胞凋亡的生存因子或化合物等手段已用于控制细胞培养过程中的细胞凋亡。这些技术将大大延长细胞达到饱和密度后的培养时间，提高细胞培养系统的生产效率。

Apoptosis(Programmed Cell Death)in Animal Cell Culture

Apoptosis(Programmed Cell Death)invariably take place in response to cell enviromental stress that cells are likely to experience in animal cell culture.With our recent understanding of the genetic and cell biology of apoptosis,there is tremendous scope for the control of apoptosis in cell culture.Methods including the expression of anti apoptotic genes using recombinant DNA technology and the supplementation of culture mediun with appropriate survival factors or anti apoptotic compounds have been utilized to control and limit apoptosis in animal cell culture.That may substantially lengthen the life span of cells that grown to saturation and improve unit process efficiency of cell culture systems.