新药原料——低毒性、抗病毒、抗肿瘤失配双链核糖核酸的研究进展

新药原料——低毒性、抗病毒、抗肿瘤失配双链核糖核酸的研究进展聂实践胡冬琴赵红罗薇（北京市营养源研究所真菌工程实验室）前言近年来，全球性病毒性疾病在不断增加，但对抗病毒药物的研究却进展缓慢。直至今日由病毒引起的恶性疾病（如恶性肿瘤，ＡＩＤＳ病等）仍无法医治，这已成为当今严重的社会问题。据统计约６０％的流行性传染病都是由病毒感染引起的，细菌感染仅占１５％。而目前世界各国批准使用的合成抗病毒药物仅...

Research Development of New Antitumor and Antivirus Material withLow Toxic Side Effect-Mismatched Double Stranded RNAs

Double-Stranded RNAs(dsRNA) are inducer of interferon,interleukin 6 and interleukin 2,which can augment human natural killer cell activity and potentiated Lymphokine actived killer cell activity.But dsRNAs are so diverse as to include those which are considered beneficial such as their immunoadjuvant effects as well as those which are considered toxic such as their pyrogenic effects.Mismatched Double-Stranded RNAs are nontoxic analogues of dsRNAs,which can affect human immune respondence without side effects.PolyI:PolyC 12 U is best compared with a lot of Mismatched Double-Stranded RNAs.