植物泛素/26S蛋白酶体途径研究进展

泛素/26S蛋白酶体途径是最重要的,有高度选择性的蛋白质降解途径，由泛素激活酶、泛素结合酶、泛素蛋白连接酶和26S蛋白酶体组成,参与调控植物生长发育的多个方面。泛素蛋白酶体途径参与植物体内的众多生理过程，如植物激素信号，光形态建成、自交不亲和反应和细胞周期等。本文就泛素/26S蛋白酶体途径以及在植物生长发育中的作用的研究近况做一综述。

The progress on The Ubiquitin 26S Proteasome Pathway in Plants

Selective protein degradation by the ubiquitin 26S proteasome pathway has emerged as a key regulatory mechanism in a wide variety of cellular processes. The ubiquitin/26S proteosome pathway mainly consists of ubiquitin activating enzyme (E1),ubiquitin conjugating enzyme (E2),ubiquitin protein ligase (E3), and 26S proteasome. In an ATP-dependent reaction,uibquitin (Ub) is conjugated to E1,the activated Ub is then transferred to an E2. Finally,the Ub-E2 intermediate delivers the Ub to the target protein by E3 recognition. Polyubiquinated proteins are eventually degraded by the 26S proteasome.In plants,regulated protein degradation by /26S proteasome pathway contributes significantly to development by affecting a wide range of progress, including hormone signaling, photomorphogenesis, self- incompatibility and cell cycle.This review highlights the recent progress towards understanding the role of the Ub/26S proteasome pathway during plant development.