| 类甜蛋白的结构特征以及功能研究进展 |
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| 引用本文： | 李文娴,刘迪秋,丁元明,葛锋,李旻,王光勇.类甜蛋白的结构特征以及功能研究进展[J].中国生物工程杂志,2010,30(3):100-104. |
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| 作者姓名： | 李文娴 刘迪秋 丁元明 葛锋 李旻 王光勇 |
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| 作者单位： | 1.昆明理工大学生命科学与技术学院 昆明 650224
2.云南出入境检验检疫局 昆明 650228 |
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| 摘 要： | 类甜蛋白是一种具有多种生物学活性及重要功能的植物防御蛋白，属于病程相关蛋白。近年来关于类甜蛋白具有抗真菌活性的研究较多。类甜蛋白具有葡聚糖酶活性，能结合并降解真菌细胞壁的组成成分—β-1,3葡聚糖酶。在三维晶体结构中类甜蛋白表面的一个酸性“V”字形裂缝对其抗真菌活性起着至关重要的作用。对类甜蛋白结构与功能的关系，不同植物中类甜蛋白的生物学特性，以及国内外基因工程中类甜蛋白基因的应用研究进展进行了综述。
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| 关 键 词： | 类甜蛋白 病程相关蛋白 V字形裂缝 葡聚糖酶活性 |
| 收稿时间： | 2009-11-03 |
| 修稿时间： | 2010-01-04 |
Research Progress in the Structural Features and Functions of Thaumatin-like Proteins |
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| LI Wen-xian LIU Di-qiu DING Yuan-ming GE Feng LI Ming WANG Guang-yong.Research Progress in the Structural Features and Functions of Thaumatin-like Proteins[J].China Biotechnology,2010,30(3):100-104. |
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| Authors: | LI Wen-xian LIU Di-qiu DING Yuan-ming GE Feng LI Ming WANG Guang-yong |
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| Institution: | LI Wen-xian1 LIU Di-qiu1 DING Yuan-ming2 GE Feng1 LI Ming2 WANG Guang-yong 1 (1 College of Life Science , Technology,Kunming University of Science , Technology,Kunming 650224,China) (2 Yunnan Entry-exit Inspection , Quarantine,Kunming 650228,China) |
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| Abstract: | Thaumatin-like proteins (TLPs) are a kind of plant defense proteins with many biological activities and functions. TLPs belong to the fifth grou Pof pathogenesis-related proteins. There are many researches on antifungal activity of TLPs in recent years. TLPs exhibit the glucanase activity, and they can bind and digest β-1,3 glucan which is a major component of fungal cell wall. In the crystal structure of TLPs, an acidic cleft on the surface of the protein appears to be necessary for antifungal activity. The relation between the structure and function, biological characteristics, and application in transgenic engineering about TLPs were reviewed. |
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| Keywords: | Thaumatin-like proteins Pathogenesis-related proteins Cleft Glucanase activity |
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