癌蛋白D52家族研究进展

肿瘤蛋白D52家族近年来引起了人们的研究兴趣。D52最早是从人乳腺癌中发现的。该家族成员分子中都含有一个叫做Coli-Coli基序的高度保守结构域，这个结构域在低等生物到哺乳动物或者同种生物的不同成员间也是高度保守的。已有的研究表明该家族成员可以通过选择性剪接的方式产生功能不同的拼接体。D52家族基因在多种癌症中广泛扩增，蛋白表达水平升高。目前认为，他们的基因功能可能与包括癌症在内的人类疾病相关，关于这个家族成员发挥作用的分子机制还有待于进一步的探讨。

Advances in Research on Tumor Protein D52 Family

Recently tumor protein D52-like proteins, the first member of which was found in human breast carcinoma, attract increasing research interests. All D52-like proteins are small coil-coil motif bearing proteins which are conserved from lower organism to human being and among the same species. Alternative splicing is producing numbers of isoforms which play different function roles．D52-like genes amplify in multicarcinoma，with the protein expression increasing．The diverse functions of D52-like proteins, which may concern with human disease including cancer, and how they play in vital are not clear so far. Further studies may highlight their function and the mechanism them work.