转铁蛋白/转铁蛋白受体介导的药物运输

转铁蛋白 转铁蛋白受体介导的铁吸收过程是哺乳动物吸收铁的主要途径。近几十年的研究 ,对此过程有了充分了解。作为靶向配体 ,转铁蛋白可以介导多种金属的运输。最新研究表明转铁蛋白可以与抗癌药物、蛋白质、基因等形成复合物 ,靶向肿瘤、血脑屏障、快速分裂等大量表达转铁蛋白受体的组织。转铁蛋白偶联的药物具有靶向性强、毒副小的优点。综述了转铁蛋白 转铁蛋白受体介导的药物运输的最新研究进展。

Transferrin/Transferrin Receptor-Mediated Drug Delivery

Transferrin/Transferrin Receptor mediated endocytosis process is a major pathway of entry of iron into mammalian cells.Intensive studies have been directed to greatly understand it in the past decades. As a target oriented ligand,Transferrin/Transferrin Receptor mediated endocytosis process provides a specific pathway for delivery a variety of metals .In the past few years,many considerable reasearches have shown that Transferrin conjugated with anticancer,proteins and genes can target into tumor cell,the bloods brain barrian and proliferating tissues which overexpress Transferring Receptor. Drugs coupled to Transferrin have many good features for high targeting and low toxin sides.This review conludes the recent progress in Transferrin/Transferrin Receptor mediated drug delivery.