EIAV与HIV分子生物学相关性研究进展

马传染性贫血病毒 (equineinfectiousanemiavirus,EIAV)与人类免疫缺陷病毒(humanimmunodeficiencyvirus ,HIV)同属逆转录病毒科、慢病毒属成员。两者在形态结构、抗原特性、基因组构成以及病毒与宿主的持续作用等方面极为相似 ,且EIAV具有独特的快速发病进程和明显的病程分界 ,使其成为研究HIV的基因变异与临床症状之间相互关系的理想动物模型。EIAV疫苗是我国拥有自立知识产权的世界上唯一的慢病毒疫苗 ,以该疫苗为基础 ,开发新型HIV疫苗将成为今后的发展策略。近年国内外学者对EIAV及HIV的分子生物学进行了深入研究 ,确定了与病毒毒力相关的某些基因及编码蛋白 ,并在疫苗的研究上取得了一定进展。

Research Advance of Molecular Biological Relativity of EIAV and HIV

Equine infectious anemia virus (EIAV), a retrovirus of lentivirus,is genetically and antigenically related to Human immunodeficiency Virus (HIV). EIAV causes acute disease and following clear disease course, which made it as an ideal animal model to probe the relation of gene variation and clinical symptom. An attenuated EIAV vaccine with an independent intellectual property right in China has been used successfully in the mainland over past decades. A program had been carried out to exploit a new HIV vaccine based on the mechanism of EIAV vaccine. Recently, many further studies about the molecular biology of EIAV and HIV are under way abroad. Some genes and their encoded proteins related to virulence have been identified, and some progress on development of vaccine have been achieved.;