类弹性蛋白多肽及其在生物医学材料的应用

类弹性蛋白多肽是一种人造基因工程蛋白质聚合物，其结构主要由五肽重复串连序列单元 (GVGXP) 的这一肽段单元重复组成。由于具有可逆相变特征，并可进行高通量生产，加之良好的生物相容性及生物可降解性，使其在新型生物医学材料方面展示了广阔的应用前景。概括了类弹性蛋白多肽的相变机理、合成方法及在生物医学材料上的应用，重点阐述了类弹性蛋白多肽在组织工程、靶向肿瘤、构造药物载体微粒的应用。

Advances in Applications of Elastin-like Polypeptides in Biomedical Materials

Elastin-like polypeptides(ELPs) were a family of artificial, genetically encodable polypeptidesthey are primarily composed of the repeating pentapeptide sequence GVGXP. Due to their reversible phase transition characteristics, ultra-high production, excellent biocompatibility and biodegradation, ELPs had an intensive potential in new biomedical materials. Describes principle of ELPs’ phase transition, and its applications in biomedical materials,especially gives emphasis to introduce the applications of tissue engineering, targeting tumor and constructing of drug carrier particle.