基因组印迹的起动与沉默

在配子中基因组印迹起动复合物的结合引发印迹现象,印迹起动复合物中有多种可鉴定成分,存在结合的精确时间和机制,印迹起动复合物似乎仅出现在生殖细胞系,而甲基CpG结合蛋白则能延续增殖印迹,因此基因组印迹调节着发育基因或组织特异性单等位基因的瞬时表达及大染色体结构域中基因之间的相互作用 。

Initiation and Silencing in Genomic Imprinting

The assembly of the imprint initiation complex resulted in all the relevant regions where gametic imprints are introduced. It should be possible to identify the components presented within the imprint initiation complex and to exist the precise timing and mechanism of their assembly. The imprint initiation complex is likely to be confined to the germ line, whereas methyl-CpG-binding proteins could be used for subsequent propagation of the imprints. Therefore,the imprints modulate the temporal and tissue-specific monoallelic expression of genes duing development and interactions between genes within large chromosomal domains.