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Cytomegalovirus seropositivity is associated with glucose regulation in the oldest old. Results from the Leiden 85-plus Study |
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| Authors: | Sijia Chen Anton JM de Craen Yotam Raz Evelyna Derhovanessian Ann CTM Vossen Rudi GJ Westendorp Graham Pawelec Andrea B Maier |
| Institution: | 1. Department of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands 2. Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, Leiden, the Netherlands 3. T??bingen Ageing and Tumour Immunology Group, Center for Medical Research, University of T??bingen Medical School, T??bingen, Germany 4. Department of Medical Microbiology, Leiden University Medical Center, Leiden, the Netherlands |
| Abstract: | ABSTRACT: BACKGROUND: Cytomegalovirus (CMV) infection has been reported to contribute to the pathogenesis of type 1 diabetes and post-transplantation diabetes. However, CMV infection has not been evaluated as a possible risk factor for type 2 diabetes. Our aim was to investigate potential associations between CMV seropositivity, CMV IgG antibody level and glucose regulation in the oldest old. RESULTS: CMV seropositive subjects were more likely to have type 2 diabetes (17.2% vs 7.9%, p = 0.016), had a higher level of HbA1c (p = 0.014) and higher non-fasting glucose (p = 0.024) in the oldest olds. These associations remained significant after adjustment for possible confounders. CMV IgG antibody level was not significantly associated with glucose regulation (all p > 0.05). CONCLUSIONS: In the oldest old, CMV seropositivity is significantly associated with various indicators of glucose regulation. This finding suggests that CMV infection might be a risk factor for the development of type 2 diabetes in the elderly. |
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