| 流感病毒血凝素基因、神经氨酸酶基因在小鼠中的免疫效果观察 |
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| 引用本文： | 周旭,李益民,侯玲,王若愚,戴欣.流感病毒血凝素基因、神经氨酸酶基因在小鼠中的免疫效果观察[J].微生物学免疫学进展,2001,29(1):15-19. |
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| 作者姓名： | 周旭 李益民 侯玲 王若愚 戴欣 |
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| 作者单位： | 兰州生物制品研究所,兰州,730046 |
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| 基金项目： | 本课题为甘肃省自然科学基金资助项目(ZS991-A23-066-Y) |
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| 摘 要： | 流感病毒血凝素基因，神经氨酸酶基因免疫BALB／c小鼠，获得特异阳性抗体反应，抗体滴度与基因免疫量呈正相关性，各实验组免疫小鼠抗同型流感病毒攻击存活率为100％，血凝素基因免疫小鼠抗异型流感病毒攻击存活率为100％，神经氨酸酶基因免疫小鼠抗异型流感病毒攻击存活率为75％，血凝素基因与神经氨酸酶基因联合免疫小鼠抗异型流感病毒攻击存活率为100％。
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| 关 键 词： | 流感病毒 血凝素基因 神经氨酸酶基因 核酸免疫 免疫效果 |
| 文章编号： | 1005-5673(2001)-01-0015-05 |
| 修稿时间： | 2000年4月24日 |
Immune effect of hemaglutinin (HA) gene and Neuraminidase (NA) gene of Influenza virus |
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| ZHOU Xu,LI Yi min,HOU Ling,et al.Immune effect of hemaglutinin (HA) gene and Neuraminidase (NA) gene of Influenza virus[J].Progress In Microbiology and Immunology,2001,29(1):15-19. |
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| Authors: | ZHOU Xu LI Yi min HOU Ling |
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| Abstract: | Applying HA gene of and NA gene influenza virus to immunize BALB/c mice,the apparent specific reaction was observed.The titer of antibody was shown a positive correlation with the amount of applied genes.The livability of immunized mice were 100%,after challenging with the same type of influenza virus in each tested group.The livability of HA gene immunized mice were 100%,challenging with hetero type of the virus.The livability of NA gene immunized mice were 75%,challenging with hetero type of the virus.The mice were attacked by hetero type of the virus,which were immunized by the combination of HA gene and NA gene,their livability were 100%. |
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| Keywords: | Influenza virus Hemagglutinin gene Neuraminidase gene Nucleic acid immune |
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