Ⅲ价轮状病毒基因重配疫苗稳定性研究

为了研究Ⅲ价轮状病毒基因重配疫苗的稳定性,对2~8℃、25℃、37℃放置不同时间的9批成品疫苗定期取样观察外观物理性状、检测病毒滴度。结果表明,在2~8℃可保存两年以上,疫苗滴度保持不变;在25℃放置2周、37℃放置1周后疫苗滴度开始下降,因此,该疫苗在贮存、运输以及使用过程中环境温度应以2~8℃为宜。

Study on the stability of the trivalent reassortant rotavirus vaccine

In order to study the stability of the trivalent reassortant rotavirus vaccine,the titers and characteristics of vaccines placed at 2-8℃,25℃ and 37℃ for different time were tested.The tested results showed that rotavirus vaccines are still effective when they are stored at 2-8 ℃ for 24 months,and the time of titer reduction for vaccine stored at 25℃ is two weeks,but that is one week stored at 37℃.In conclusion,the environmental temperature of 2-8℃ is more suitable for vaccine storage,use and transportation.