| 硫酸镍对人红细胞膜Na~+、K~+、Ca~(2+)-ATP酶及乙酰胆碱酯酶活力的影响 |
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| 引用本文： | 路东,张岩锐,寇桂英,朱玉梅,罗广,付萍.硫酸镍对人红细胞膜Na~+、K~+、Ca~(2+)-ATP酶及乙酰胆碱酯酶活力的影响[J].微生物学免疫学进展,2005,33(4):39-43. |
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| 作者姓名： | 路东 张岩锐 寇桂英 朱玉梅 罗广 付萍 |
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| 作者单位： | 1. 兰州生物制品研究所,兰州,730046
2. 兰州大学,兰州,730000 |
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| 摘 要： | 实验研究了硫酸镍对人红细胞膜Na+、K+、Ca2+-ATP酶及乙酰胆碱酯酶(AChE)活力的影响,为从分子水平阐明镍毒作用机理及为探索防治措施提供依据。结果表明,硫酸镍对此三种酶均有抑制作用,并呈现较高的量效关系及时效关系。
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| 关 键 词： | 硫酸镍 细胞膜 酶活力 |
| 文章编号： | 1005-5673（2005）04-0039-05 |
| 收稿时间： | 2005-04-19 |
| 修稿时间： | 2005-05-23 |
The effect of NiSO4 on activities of Na+,K+, Ca2+- ATPase and acetycholines terase(AChE) in human red cell membrane |
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| LU Dong, ZHANG Yan-rui, KOU Gui-ying.The effect of NiSO4 on activities of Na+,K+, Ca2+- ATPase and acetycholines terase(AChE) in human red cell membrane[J].Progress In Microbiology and Immunology,2005,33(4):39-43. |
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| Authors: | LU Dong ZHANG Yan-rui KOU Gui-ying |
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| Institution: | 1. Lanzhou Institute of Biological products, Langzhou 730046,China; 2. Lanzhou University, Langzhou 730000 China |
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| Abstract: | In order to clarify effect of nickel(Ni) poison in the molecular level and to explore the basis of related prevention and curative measures,we investigated the effect of nickel sulfate(NiSO_(4))on activities of Na~( ),K~( ),Ca~(2 )-ATPase and AchE in human red cell membrane.The result shows that the activities of three enzymes are inhibited by NiSO_(4) and the relationship between the quality-effect and time-effect does exist,which needs to be further studied. |
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| Keywords: | NiSO_(4) Cell membrane Enzyme activity |
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