| 噬菌体抗体库筛选技术研究进展 |
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| 引用本文： | 毕司英.噬菌体抗体库筛选技术研究进展[J].微生物学免疫学进展,2012,40(1):70-73. |
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| 作者姓名： | 毕司英 |
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| 作者单位： | 兰州生物制品研究所,兰州,730046 |
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| 摘 要： | 噬菌体抗体库技术是一项新兴的基因工程抗体技术,应用这项技术获得高特异性抗体的关键之一就是筛选环节。根据抗原性质以及筛选目的的不同,筛选方法的选择也不相同,各种筛选策略的优化对中和抗体的获得有至关重要的作用。
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| 关 键 词： | 噬菌体展示 噬菌体抗体库 筛选技术 优化 |
The advances on screening technology of phage-display antibody libraries |
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| BI Si-ying.The advances on screening technology of phage-display antibody libraries[J].Progress In Microbiology and Immunology,2012,40(1):70-73. |
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| Authors: | BI Si-ying |
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| Institution: | (Lanzhou Institute of Biological Products,Lanzhou 730046, China) |
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| Abstract: | Phage antibody library is a new engineered antibody technology,the screening procedure is important to obtain highly specific antibodies.According to the property of antigens and screening purposes,the screening methods are different.The optimization of screening strategy is critical to obtain neutralizing antibodies. |
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| Keywords: | Phage display Phage antibody library Screening technology Optimization |
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