| NLRP3炎症体与炎症性疾病 |
| |
| 引用本文： | 蒋建烨,田湉.NLRP3炎症体与炎症性疾病[J].微生物学免疫学进展,2012,40(1):79-82. |
| |
| 作者姓名： | 蒋建烨 田湉 |
| |
| 作者单位： | 南华大学病原微生物研究所,衡阳,421001 |
| |
| 基金项目： | 湖南省教育厅重点项目,湖南省大学生研究性学习和创新性实验计划项目 |
| |
| 摘 要： | 炎症体是胱天蛋白酶的活化平台,并促进一些前炎症细胞因子如IL-1β、IL-18和IL-33的成熟,启动机体的先天性免疫防御功能。炎症体的激活和失调与人类先天及后天的炎症性疾病都密切相关。通过对NLRP1、NL-RP3、IPAF和AIM2炎症体调节机制的研究,可为家族性周期性自身炎症反应、痛风、II型糖尿病等的治疗提供新的靶点。主要就NLRP3炎症体的组成、分布和调节机制及与NLRP3炎症体相关的炎症性疾病进行了简要介绍。
|
| 关 键 词： | 炎症体 NLRP3 IL-1β |
NLRP3 inflammasomes and inflammatory diseases |
| |
| JIANG Jian-ye
,
TIAN Tian.NLRP3 inflammasomes and inflammatory diseases[J].Progress In Microbiology and Immunology,2012,40(1):79-82. |
| |
| Authors: | JIANG Jian-ye TIAN Tian |
| |
| Institution: | (Institute of Pathogens of University of South China,Hengyang 421001,China) |
| |
| Abstract: | Inflammasomes is a platform of caspase activation that trigger the maturation of proinflammatory cytokines such as interleukin-1β,IL-18 and IL-33 to engage innate immune defenses.The activation and disproportion of inflammasome is highly relevant to human heritable and acquired inflammatory diseases.Regulatory mechanism of the NLRP1,NLRP3,IPAF and AIM2 inflammasomes are linked a number of diseases such as familial periodic self-inflammation,gout,T2D which can provide some new targets for clinical treatment.This review will mainly introduce the composition,distribution and regulatory mechanism of inflammasome and inflammatory diseases associated with NLRP3. |
| |
| Keywords: | Inflammasome NLRP3 IL-1β |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
