| 乙型肝炎疫苗-卡介苗联合疫苗动物安全性试验研究 |
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| 引用本文： | 杨丽华,王志,赵亚力,赵晓青,于爱东,蔡岩,杨彤,赵小林,金立杰.乙型肝炎疫苗-卡介苗联合疫苗动物安全性试验研究[J].微生物学免疫学进展,2007,35(1):19-21. |
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| 作者姓名： | 杨丽华 王志 赵亚力 赵晓青 于爱东 蔡岩 杨彤 赵小林 金立杰 |
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| 作者单位： | 长春生物制品研究所,长春,130062 |
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| 摘 要： | 为评价乙型肝炎疫苗-卡介苗联合疫苗的安全性,分别给豚鼠皮下注射、小鼠皮内注射乙型肝炎疫苗-卡介苗联合疫苗或卡介苗,豚鼠每2周称体重一次,观察6周,解剖检查其病理变化;小鼠也进行病理检查。结果乙型肝炎疫苗-卡介苗联合疫苗接种组和卡介苗接种组的豚鼠体重均增加,疫苗注射局部及各脏器病理改变相似;小鼠接种局部皮肤病理改变也未见差异。结论为乙肝表面抗原(HBsAg)没有促使卡介苗毒力增强,乙型肝炎疫苗-卡介苗联合疫苗接种实验鼠是安全的。
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| 关 键 词： | 乙型肝炎疫苗 卡介苗 联合疫苗 安全性 |
| 文章编号： | 1005-5673（2007）01-0019-03 |
| 收稿时间： | 2006-07-17 |
| 修稿时间： | 2006-09-21 |
Study on safety of hepatitis B-BCG combined vaccine in animal experiment |
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| YANG Li-hua , WANG Zhi ,ZHAO Ya- li,et al..Study on safety of hepatitis B-BCG combined vaccine in animal experiment[J].Progress In Microbiology and Immunology,2007,35(1):19-21. |
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| Authors: | YANG Li-hua WANG Zhi ZHAO Ya- li |
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| Institution: | Changchun Instititue of Biological Products, Changchun130062, China |
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| Abstract: | To evaluate on the safety of Hepatitis B-BCG combined vaccine in animal experiment,Hepatitis B-BCG combined vaccine and BCG were inoculated in the guinea pig by hypodermic injection and BALB/C mice by injection respectively and checked up pathologic changes.The pathologic changes of the vaccinated skin and organs were similar in combined vaccine group and in BCG group.There was no significant difference related to the pathological characters in the inoculated skin of BALB/C mice.It was not observed that HBsAg made BCG's toxicity increased.The result showed that Hepatitis B-BCG combined vaccine was safe in animal test. |
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| Keywords: | Hepatitis B vaccine BCG Combined vaccine Safety |
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