乙型肝炎病人重叠感染丙型肝炎的评价

应用ＥＬＩＳＡ和ＰＣＲ法检测５０２例乙肝病人血清，４０１例ＨＢｓＡｇ阳性血清中，有１１４例（２８．４％）抗－ＨＣＶ和ＨＣＶＲＮＡ双项阳性，２５例（６．２％）ＨＣＶＲＮＡ单项阳性；２１例（５．２％）抗－ＨＣＶ单项阳性。将ＨＢｓＡｇ乙肝病人分成ＨＢＶＤＮＡ，ＨＢｅＡｇ阳性组和ＨＢＶＤＮＡ，ＨＢｅＡｇ阴性组。前者抗－ＨＣＶ阳性率为１１．６％～２０．５％，ＨＣＶＲＮＡ阳性率为１６．２％～２０．５％。后者抗－ＨＣＶ阳性率为２０．２％～５５．６％，ＨＣＶＲＮＡ阳性率为２３％～６０．３％。结果说明长期携带ＨＢＶ者和慢性乙肝病人均可重叠ＨＣＶ感染。ＨＢＶＤＮＡ阳性组抗－ＨＣＶ和ＨＣＶＲＮＡ阳性率明显高于ＨＢＶＤＮＡ阳性组

Evaluation of Hepatitis C Virus Coinfection in Patients with Hepatitis B

The objects were evaluated to determine whether they were infected with the hepatitis C virus (HCV) in patients with hepatitis B virus (HBV).The patients were infected by either HBV or HCV.But,the incidence and mortality might highly increased in patients with HBV nd HCV coinfection.The Sera collect from 502 patients with hepatitis B were detected by ELISA and PCR methods.401 cases are HBsAg serpositive.114 (28.4%) specimens were found to be both anti-HCV and HCV RNA postitive by ELISA and PCR asseay,25(6.2%) specimens are HCV RNA positive alone,21 (5.2%) specimens are anti-HCV positive alone.The patients with hepatitis B of HBsAg positive divided into HBV DNA and HBeAg positive group;HBV DNA and HBeAg negative group.The prevalence of anti-HCV is 11.6%-20.5%.The positive rate of HCV RNA is 16.2%-20.5% in HBV DNA and HBeAg positive group;the prevalence of anti-HCV is 20.2%-55.6%,HCV RNA is 23%-60.3% in HBV DNA and HBeAg negative group. The present study demonstrates that HCV coinfection may occur in long-term HBV carriers and patients with chronic hepatitis B.The data indicate that prevalence of anti-HCV and HCV RNA in HBV DNA negative patients significantly higher than that of patients of HBV DNA positive.In conclusion HCV is a very important cause in HBsAg negative patients with chronic hepatitis B.That must be chiefly monitored for HCV coinfection during clinical HBV DNA negative of patients with chronic hepatitis B.