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冻干神经生长因子活性稳定性试验研究
引用本文:沈心亮,翟雷.冻干神经生长因子活性稳定性试验研究[J].微生物学免疫学进展,1998,26(3):54-56.
作者姓名:沈心亮  翟雷
作者单位:卫生部兰州生物制品研究所
摘    要:用不同的物质作保护剂冻干纯化鼠神经生长因子,经检定以人血白蛋白作为赋形剂和保护剂冻干神经生长因子制品外观洁白细腻,结构强度良好,生物活性符合要求,残存水分低于3%。采用留样观察法检测其稳定性,将制品放置4℃~8℃,在0、0.5、1、2、3、6、9、12、18、24、25个月分别测定其各自的活性。结果表明神经生长因子冻干制品在4℃~8℃保存,25个月仍然保持原有生物活性

关 键 词:神经生长因子  冻干保护剂  稳定性

Stability of Lyophilized Nerve Growth Factor
Abstract:The purified mouse NGF were lyophilized respectively with different substances as protecting reagents.Best results were obtained when human serum albumin (HAS) was used as protecting medium.It showed good appearance and moisture residue was less than 3%.The stability of the lyophilized products in this medium were tested.After 25 months,the activity of lyophilized products did not decrease when products were stored between 4℃-8℃.
Keywords:Nore Growth Factor  Lyophilized protecting medium  Stability  
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