| 治疗性乙肝疫苗研究及疗效考核 |
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| 引用本文： | 姚伟,郑菊梅.治疗性乙肝疫苗研究及疗效考核[J].微生物学免疫学进展,1998,26(3):50-53. |
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| 作者姓名： | 姚伟 郑菊梅 |
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| 作者单位： | 卫生部兰州生物制品研究所 |
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| 摘 要： | 我们采用治疗性乙肝疫苗（免疫复合物型和佐剂型）分别对１４５例各型乙型肝炎进行治疗，结果显示：乙肝主要指标ＡＬＴ复常率、ＨＢＶ－ＤＮＡ及ＨＢｅＡｇ阴转率，免疫复合物组分别为９２．９％、５０％和４１．９％；佐剂组分别为９４．１％、４２．８％和３５．２％，均明显高于对照组（Ｐ＜０．０１）。Ｔ细胞亚群中ＣＤ＋４／ＣＤ＋８细胞平均比值明显提高。试验表明：免疫复合物型疫苗和佐剂型疫苗对慢性肝炎，尤其是慢性活动性肝炎有较好疗效，而免疫复合物型优于佐剂型。本制剂无毒副作用，为生物制剂治疗乙型肝炎开辟了一条新途径
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| 关 键 词： | 治疗性乙肝疫苗 免疫复合物 佐剂 乙型肝炎 |
The Study and Analysis of Curative Effect of Therapeutic Hepatitis B Vaccine |
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| Institution: | Lanzhou Institute of Biological Products Lanzhou 730046 |
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| Abstract: | 145 cases of the hepatitis B were treated with Therapeutic Hepatitis B Vaccine (THBV,type immune complexes and type adjuvant).The results showed that the recovery rate of ALT and the negative conversion rate of HBV-M were 92.9%,50% and 41.9% in type immune complexes and they were 94.1%,42.8% and 35.2% in type adjuvant.They were higher significantly than those in normal controls (P<0.01).The ratios of CD+4/CD+8 rose obviously.The results indicated that THBV is efficacious for various hepatitis,especially for CAH.The curative effect of the type immune complexes is better than the type adjuvant. |
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| Keywords: | Therapeutic Hepatitis B Vaccine Immune Compleses Adjuvant Hepatitis B |
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