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Melanoma central nervous system metastases: An update to approaches,challenges, and opportunities |
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| Authors: | Zeynep Eroglu Sheri L Holmen Qing Chen Nikhil I Khushalani Ravi Amaravadi Reena Thomas Kamran A Ahmed Hussein Tawbi Sunandana Chandra Joseph Markowitz Inna Smalley James K C Liu Yian Ann Chen Yana G Najjar Florian A Karreth Daniel Abate‐Daga Isabella C Glitza Jeffrey A Sosman Vernon K Sondak Marcus Bosenberg Meenhard Herlyn Michael B Atkins Harriet Kluger Kim Margolin Peter A Forsyth Michael A Davies Keiran S M Smalley |
| Abstract: | In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System (CNS) Metastases in Tampa, Florida. In this white paper, we outline the current status of basic science, translational, and clinical research into melanoma brain metastasis development and therapeutic management. We further outline the important challenges that remain for the field and the critical barriers that need to be overcome for continued progress to be made in this clinically difficult area. |
| Keywords: | brain metastases immunotherapy melanoma metastasis targeted therapy |