Dynamics of calcium release and uptake by the internal calcium stores in rat sensory neurons |
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Authors: | E V Khomula N V Voitenko |
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Institution: | (1) Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine |
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Abstract: | Calcium dynamics in the endoplasmic reticulum of dorsal root ganglion neurons of rats during Ca2+ release induced by caffeine and subsequent Ca2+ uptake were studied. Calcium release is shown to include two (a short transient and a prolonged slow) phases. We suggest
that the transient phase reflects release of free Ca from the calcium store, while the slow phase reflects transition of Ca
from a bound form to a free one. The process of Ca2+ uptake is characterized by exponential recovery of the calcium level in the store due to the SERCA activity.
Neirofiziologiya/Neurophysiology, Vol. 38, No. 4, pp. 361–363, July–August, 2006. |
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Keywords: | dorsal root ganglion neurons endoplasmic reticulum calcium stores caffeine |
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