Abstract: | Respiratory diseases affect millions of people all over the world. The main lesions occur in trachea, bronchus, lung and chest. The mild ones have cough and chest pain, while the severe ones have dyspnea, hypoxia and even respiratory failure, resulting in a variety of complications leading to severe disability and even death. Clinical use of therapeutic antibodies has opened up a new way for the treatment of lung cancer, asthma and various respiratory infectious diseases. At present, dozens of antibodies (Abs) have been approved into the market, and more antibodies are under clinical development. Most of these Abs are aimed at asthma, lung cancer, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and respiratory infectious diseases. Among them, the outbreak of respiratory infectious diseases has the characteristics of rapid spread and strong infectivity, which often causes global concern, such as coronavirus disease 2019 (COVID-19), which is now raging all over the world. A variety of Abs for respiratory infectious diseases provides new strategies for their clinical treatment. Based on this situation, Abs, which have been approved and are being developed clinically, were reviewed. The molecular mechanisms, advantages and development trend of antibody therapy were summarized in order to provide references for the research and development of Abs in the treatment of respiratory infectious diseases. |