FAM96A和FAM96B结构与功能的研究进展

96序列相似的家庭成员A和B（family with sequence similarity 96 member A and B，FAM96A和FAM96B）是属于MIP18（MMS19-interacting protein of 18 kD）家族的2个高度保守的同源蛋白，MIP18是与有丝分裂纺锤体相关的MMDX（MMS19-MIP18-XPD）复合体的亚基。研究表明，FAM96A和FAM96B在人胃肠道间质瘤、结肠癌、肝癌、胃癌和乳腺癌等多种肿瘤组织中的表达显著降低，提示其可能是作为潜在的抑癌基因参与肿瘤的发生发展，但目前关于FAM96A和FAM96B在肿瘤发生发展过程中的作用机理并不十分清楚。此外，研究发现FAM96A和FAM96B可通过与其他不同的蛋白质相互作用在体内发挥多种不同的功能。因此，就目前对于FAM96A和FAM96B结构和功能的研究所取得的进展进行了回顾与总结，并对其在肿瘤发生发展中的分子机制和相互作用蛋白鉴定的研究前景进行了展望，以期为临床上将FAM96A和FAM96B作为新的肿瘤诊断标志物和治疗靶点奠定基础，并为揭示二者在体内更多的新功能提供依据。

Progress on Structure and Function of FAM96A and FAM96B

Family with sequence similarity 96 member A and B(FAM96A and FAM96B)are two highly conserved homologous proteins belonging to MIP18(MMS 19-interacting protein of 18 kD)family.MIP18 is a subunit of MMDX(MMS19-MIP18-XPD)complex related to mitotic spindle.Studies have shown that the expressions of FAM96A and FAM96B in human gastrointestinal stromal tumors,colon cancer,liver cancer,gastric cancer and breast cancer are significantly decreased compared with corresponding normal tissues,suggesting that they may participate in the occurrence and development of tumors as potential tumor suppressor genes.However,the molecular mechanisms of FAM96A and FAM96B in the occurrence and development of tumors are not very clear at present.In addition,it was found that FAM96A and FAM96B could play a variety of different functions in vivo by interacting with other different proteins.Therefore,the research progress on the structure and function of FAM96A and FAM96B was reviewed and summarized,and the research prospect of molecular mechanism and identification of interacting proteins in tumor development was prospected,in order to lay a foundation for clinical use of FAM96A and FAM96B as new tumor diagnostic markers and therapeutic targets,and provide a basis for revealing more new functions of FAM96A and FAM96B in vivo.