Preparation and duplex-to-single strand transition of the fully complementary duplex of d(G4).d(C4) in aqueous solution |
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| Authors: | T Shinoda T Wada S Ohuchi T Hata |
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| Institution: | National Chemical Laboratory for Industry, Tsukuba Research Center, Ibaraki, Japan. |
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| Abstract: | The d(G4) and d(C4) molecules in the single stranded state were synthesized by the phosphotriester method and purified. The full duplex of tetramer d(G4).d(C4) was prepared by expending about a month. The duplex-to-single strand transition was observed by UV-spectroscopy. A standard hypochromic effect was observed, which is different from some experimental results reported previously. |
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