Cells of patients with ataxia telangiectasia show a normal capacity of radio-induced reactivation of damaged HSV-1 virus |
| |
| Authors: | G Hilgers P J Abrahams R Schouten J J Cornelis A R Lehmann A J Van der Eb J Rommelaere |
| |
| Institution: | MRC Cell Mutation Unit, University of Sussex, Falmer, Brighton, United Kingdom. |
| |
| Abstract: | Herpes Simplex Virus (HSV-1) was used to probe the expression of enhanced reactivation (ER) in cells from patients with ataxia telangiectasia (AT). The survival of UV-irradiated HSV-1 was increased as a result of UV- or X-preirradiation of both AT and normal cells. This result contrasts with our previous observation showing that contrary to normal cells AT cells are deficient for ER of a single-stranded DNA parvovirus. A difference between the molecular processes underlying ER of single- and double-stranded DNA viruses might explain these results. |
| |
| Keywords: | |
|
|
