| COX-2及其抑制剂在肿瘤防治中的作用 |
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| 引用本文： | 向阳,孙敏,王和勇.COX-2及其抑制剂在肿瘤防治中的作用[J].生命科学,2008,20(1):81-85. |
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| 作者姓名： | 向阳 孙敏 王和勇 |
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| 作者单位： | 1. 西南大学生命科学学院,重庆,400715
2. 同济大学附属上海市肺科医院,上海,200433 |
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| 摘 要： | 环氧化酶（cyclooxygenase，COX）是前列腺素合成途径中主要的限速酶之一，参与炎症、发热、出凝血等病理生理过程。COX-2在肿瘤发生发展、转移、凋亡抑制及促进肿瘤血管生成等方面发挥重要作用，己成为肿瘤防治的一个新靶点；COX-2及其抑制剂在肿瘤预防、放疗、化疗、生物疗法中具有广阔应用前景。本文就COX-2及其抑制剂在肿瘤防治中的进展作一详细综述。
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| 关 键 词： | COX-2 抑制剂 肿瘤预防 肿瘤治疗 |
| 文章编号： | 1004-0374（2008）01-0081-05 |
| 收稿时间： | 2007-08-06 |
| 修稿时间： | 2007-10-30 |
The function of COX-2 and it's inhibitors in tumor prevention and treatment |
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| XIANG Yang,SUN Min,WANG He-yong.The function of COX-2 and it's inhibitors in tumor prevention and treatment[J].Chinese Bulletin of Life Sciences,2008,20(1):81-85. |
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| Authors: | XIANG Yang SUN Min WANG He-yong |
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| Institution: | XIANG Yang, SUN Min, WANG He-yong (1 School of Life Science, Southwest University, Chongqing 400715, China; 2 Pulmonary Hospital, Tongji University, Shanghai 200433, China) |
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| Abstract: | Cyclooxygenase is the main rate-limiting enzyme in the prostaglandin synthesis, which participates in inflammation, fever, hemoglutination and so on. COX-2 plays a vital role in the tumor occurrence, angiogenesis, metastasis as well as apoptosis inhibition. Therefore, COX-2 has become a new target in tumor treatment. COX-2 and its inhibitors have a broad prospect in the tumor prevention, chemotherapy, radiotherapy and biotherapy. This article reviews recent research progress of COX-2 and its inhibitors in tumor preventing and controlling. |
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| Keywords: | COX-2 inhibitor tumor prevention cancer therapy |
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