模式识别受体介导的病原免疫逃逸 |
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引用本文: | 胡茂志,;潘志明,;焦新安.模式识别受体介导的病原免疫逃逸[J].生命科学,2014(9):912-917. |
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作者姓名: | 胡茂志 ;潘志明 ;焦新安 |
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作者单位: | [1]扬州大学江苏省高校动物重要疫病与人兽共患病防控协同创新中心,扬州225009; [2]扬州大学江苏省人兽共患病学重点实验室,扬州225009 |
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基金项目: | 基金项目:国家重点基础研究发展计划(“973项目”)(2012CB518805);国家自然科学基金重点项目(31230070);国家自然科学基金项目(31372414);教育部新世纪优秀人才支持计划(NCET-12-0745) |
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摘 要: | 天然免疫通过细胞模式识别受体识别病原相关分子模式来清除感染。但是,在长期的进化过程中,许多病原体已经形成了自身的保护机制,从而逃逸天然免疫的杀伤。综述了模式识别受体介导的病原体的主要逃逸机制,以期为疾病的控制和预防提供新认识。
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关 键 词: | 病原体 模式识别受体 免疫逃逸 |
Escape mechanisms of pathogen mediated by pattern-recognition receptors |
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Institution: | HU Mao-Zhi, PAN Zhi-Ming, JIAO Xin-An. Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China; 2 Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, China ) |
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Abstract: | Innate immunity can clear the pathogen through the recognition of pathogen-associated molecular pattern recognition receptors (PRRs). But, in the long-time evolutionary process, many pathogens have developed some protective mechanisms to escape the killing of innate immunity. Here, we reviewed the research progress on escape mechanisms of patho~,ens mediated bv PRRs. in order to benefit the control and prevention of diseases. |
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Keywords: | pathogen PRRs immune escape |
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