| 昆虫抗菌肽结构与功能关系及其在分子设计中的应用 |
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| 引用本文： | 庞英明,段金廒,屈贤铭.昆虫抗菌肽结构与功能关系及其在分子设计中的应用[J].生命科学,2001,13(5):209-213. |
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| 作者姓名： | 庞英明 段金廒 屈贤铭 |
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| 作者单位： | 1. 中国药科大学天然药物资源化学研究室,南京,210038
2. 中科院上海生物工程研究中心,上海,200233 |
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| 基金项目： | 国家高技术研究发展计划资助项目(960180) |
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| 摘 要： | 昆虫抗菌肽在自然分布广泛，结构多样，其作用机制尚未确切阐明，但其结构上的某些共同特征与其功能密切相关，同时，对其结构与功能间关系的研究有利于设计合成新的抗菌肽，为以后发现活性更强，毒性更低且作用广谱的抗菌素奠定基础。
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| 关 键 词： | 昆虫抗菌肽 结构 作用机制 分子设计 |
| 文章编号： | 1004-0374(2001)05-0209-05 |
| 修稿时间： | 2000年7月25日 |
Design of synthetic antimicrobial peptides based on relation between structures and activities |
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| PANG YingMing,DUAN Jin-Ao,QU Xian-Ming.Design of synthetic antimicrobial peptides based on relation between structures and activities[J].Chinese Bulletin of Life Sciences,2001,13(5):209-213. |
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| Authors: | PANG YingMing DUAN Jin-Ao QU Xian-Ming |
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| Abstract: | Antimicrobial peptides have been isolated from insects,plants and other animals, but they differ markedly in length,sequence and structure. So they have various activities but in many aspects they share some similar mechanism of action on basis of common structures. They have been subject to numerous structure-activity relationship studies,also aimed at the elucidation of their mechanism of action, so as to easily accessible to design and solid phase synthesis. |
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| Keywords: | insect antimicrobial peptides structures mechanism of action molecular design |
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