TLRs、慢性炎症与肿瘤

Toll样受体是新发现的先天性免疫的病原模式识别受体，在机体抵抗外来病原生物入侵上起关键的作用。除了抵抗外来病原生物入侵外， Toll样受体现在也被认为与某些自身免疫性疾病、肿瘤和某些病因不明的疾病的发病有关。慢性炎症被认为在不同层面促进某些肿瘤的发生和发展，其中之一就是慢性炎症通过免疫抑制导致免疫系统对肿瘤细胞无反应，这种免疫抑制也与 Toll样受体有关。

Toll-like receptors, chronic inflammation and cancer

Toll-like receptors play a crucial role in the host defense against invading microorganisms by recognizing pathogen-associated molecular patterns. In addition, it is now known to occur under sterile conditions such as those characterizing autoimmune diseases, cancers, or diseases of unknown cause. Chronic inflammation is recognized to initiate and promote tumor development and progression in various levels. One of mechanisms is the development of an immunosuppressive environment by chronic inflammation in cancer patients, which is also related to Toll-like receptors.