EB病毒BNLF—1基因研究的新进展

EB病毒广泛存在于人群中，它的潜伏感染与鼻咽癌的发生密切相关。EBV在潜伏感染的过程中表达一种潜伏膜蛋白1（LMP1），具有致瘤性，因此编码LMP1的基因BNLF－1被认为是EBV的瘤基因。BNLF－1基因具有广泛的生物学功能，在鼻咽癌的发生发展过程中起重要作用。近年的研究表明，鼻咽癌来源的EBV与标准株EBV比较存在相当的变异，而鼻咽癌来源的LMP1在致瘤性上也明显强于标准株LMP1。本文将综述BNLF－1基因生物学功能研究方面的新进展，并简要介绍变异型LMP1研究的新成果。

New progress in researches on BNLF-1 gene of EB virus

Epstein-Bars virus ubiquitously exists in populations, its lated infection is closely associated with the incidence of nasopharyngeal carcinoma (NPC). EBV expresses LMP1 with tumorigenecity during its latent infection, therefore BNLF-1 gene encoding LMP1 is regarded as oncogene of EBV.BNLF-1 gene exhibits profound biological functions and plays an important role in the incidence of NPC. Recent studies indicate that NPC-derived EBV differs significatly from standard EBV, and tumorigenicity of NPC-derived LMP1 is significatly greater than that of standard LMP1. This review will focus on new progresses in the studies on the biological function of BNLF-1 gene and briefly introduce the new grievement of studies on the NPC-derived LMP1.