| 内质网应激与脂类代谢 |
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| 引用本文： | 孟冉,阮国良,杨代勤.内质网应激与脂类代谢[J].生命科学,2014(10):1004-1011. |
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| 作者姓名： | 孟冉 阮国良 杨代勤 |
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| 作者单位： | 长江大学动物科学学院;淡水水产健康养殖湖北省协同创新中心;湿地生态与农业利用教育部工程研究中心; |
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| 基金项目： | 公益性行业(农业)科研专项(201003076);国家科技支撑计划资助项目(2013BAD20B06) |
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| 摘 要： | 内质网应激激活的未折叠蛋白反应(unfolded protein response,UPR)是维持机体代谢平衡的重要信号通路。同时,内质网与脂类合成、转运和分解密切相关。近来研究发现UPR对脂类代谢具有调节作用。主要讨论内质网应激激活的UPR对脂类合成、转运和分解的影响及其机制。
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| 关 键 词： | 内质网应激 脂类合成 脂类转运 脂解 |
Intersection of ER stress and lipid metabolism |
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| Institution: | MENG Ran, RUAN Guo-Liang, YANG Dai-Qin (1 College of Animal Science, Yangtze University, Jingzhou 434025, China; 2 Hubei Collaborative Innovation Center for Freshwater Aquaculture, Wuhan 430070, China; 3 Engineering Research Center of Ecology and Agricultural Use of Wetland, Ministry of Education, Jingzhou 434025, China) |
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| Abstract: | The unfolded protein response （UPR） was identified as a signal transduction system that is activated by endoplasmic reticulum （ER） stress. Recent studies revealed a critical role of the UPR in lipid metabolism. This paper focuses on the mechanism of ER stress-induced signalings on lipogenesis, lipid transport and lipolysis. |
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| Keywords: | endoplasmic reticulum stress lipogenesis lipid transport lipolysis |
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