| Survivin小分子抑制剂的研究进展 |
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| 引用本文： | 赵楠,赵晓航,许杨.Survivin小分子抑制剂的研究进展[J].生命科学,2014(11):1207-1214. |
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| 作者姓名： | 赵楠 赵晓航 许杨 |
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| 作者单位： | 中国医学科学院肿瘤研究所;分子肿瘤学国家重点实验室; |
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| 基金项目： | 国家自然科学基金项目(81372385);国家高技术发展计划项目(2012AA02A503,2012AA020206) |
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| 摘 要： | Survivin是凋亡抑制蛋白家族的一员,在抑制细胞凋亡、调控细胞周期、参与血管形成等方面发挥重要的生物学功能。Survivin在多种肿瘤组织中过量表达,与肿瘤不良预后和耐药性密切相关。Survivin作为一种潜在的肿瘤治疗靶点,其小分子抑制剂用于肿瘤治疗的研究为人们所关注。概述了Survivin的结构、功能及其在肿瘤组织中的特异性表达,综述了目前靶向Survivin的小分子抑制剂的研究进展。
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| 关 键 词： | Survivin 抑制剂 肿瘤 |
Advance in small-molecule inhibitors of Survivin |
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| ZHAO Nan,ZHAO Xiao-Hang,XU Yang.Advance in small-molecule inhibitors of Survivin[J].Chinese Bulletin of Life Sciences,2014(11):1207-1214. |
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| Authors: | ZHAO Nan ZHAO Xiao-Hang XU Yang |
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| Institution: | (State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, China) |
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| Abstract: | Survivin is a member of inhibitor of apoptosis protein （IAP） family. It plays a critical biological role in many aspects including inhibiting apoptosis, regulating cell cycle and angiogenesis. Overexpression of Survivin exists in a variety of tumors, which is associated with the poor prognosis and drug resistance. As a potential target for cancer treatment, the small-molecule inhibitors of Survivin is becoming the hot point. This review provides a brief overview about Survivin structure, function, distribution in tumor, and a summary of the current progress of small-molecule inhibitors targeting Survivin. |
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| Keywords: | Survivin inhibitor tumor |
| 本文献已被 CNKI 维普 等数据库收录！ |
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